A Highly Reactive P450 Model Compound I
نویسندگان
چکیده
منابع مشابه
X-ray absorption spectroscopy of chloroperoxidase compound I: Insight into the reactive intermediate of P450 chemistry.
We report the structural characterization of a thiolate-ligated ferryl radical. Using x-ray absorption spectroscopy, we examined chloroperoxidase (CPO) compound I (CPO-I). Our results indicate that CPO-I is an authentic ferryl species with an Fe-O bond of 1.65 A. Axial-ligand interactions result in a remarkably long 2.48-A Fe-S bond. Analogous forms of cytochrome P450 and CPO have been shown to...
متن کاملDoes Compound I Vary Significantly between Isoforms of Cytochrome P450?
The cytochrome P450 (CYP) enzymes are important in many areas, including pharmaceutical development. Subtle changes in the electronic structure of the active species, Compound I, have been postulated previously to account partly for the experimentally observed differences in reactivity between isoforms. Current predictive models of CYP metabolism typically assume an identical Compound I in all ...
متن کاملI-3: Reactive Oxygen Species: A Dilemma for
Spermatozoa are very special cells and constantly exposed to the interphase between oxidative stress through high amounts of reactive oxygen species (ROS) and leukocytes, and reduction by means of scavengers and antioxidants. Considering the very special functions of spermatozoa as being the only cells with such high polarization and exerting their functions outside the body, even in a differen...
متن کاملReactivity Patterns of (Protonated) Compound II and Compound I of Cytochrome P450: Which is the Better Oxidant?
The cytochromes P450 are versatile enzymes in human physiology that perform substrate hydroxylation reactions extremely efficiently. In this work, we present results of a computational study on the reactivity patterns of Compound I, Compound II, and protonated Compound II with model substrates, and we address the question of which of these compounds is the most effective oxidant? All calculatio...
متن کاملChemorheology of a Highly Filled Epoxy Compound
Based on measurements of the dynamic viscosity, a strategy is proposed to find an expression that relates the viscosity of an epoxy compound during curing, to the temperature, shear rate, and degree of reaction. It appeared that the dynamic viscosity is a unique function of the effective shear rate (i.e. the product of frequency and strain) over a wide range of frequencies and strains after bei...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 2009
ISSN: 0002-7863,1520-5126
DOI: 10.1021/ja903394s